EPISODE · Aug 25, 2026 · 28 MIN
1490-芽孢杆菌代谢通量与蛋白质组配分脱钩机制
from 聊聊Sci
这项研究揭示了枯草芽孢杆菌与大肠杆菌在资源分配策略上的显著差异，挑战了传统的细菌生长模型。研究发现，这种细菌利用鸟苷三磷酸（GTP）而非 (p)ppGpp 作为调节蛋白质合成的核心信号，从而在面对压力时表现出独特的生理特征。在受到翻译抑制时，枯草芽孢杆菌会解耦代谢通量与蛋白质组组成，通过代谢反馈调节而非大规模重组蛋白质结构来应对。这种策略虽然在生长速度上并非最优，但却在生长效率与抗逆生存之间达成了关键的平衡。此外，这种基于 GTP 的控制机制在厚壁菌门中具有进化上的普遍性，展示了细菌适应环境的多样化路径。References:Thiermann R, Yang J, Zodage A, et al. Decoupling of global metabolic flux and proteome partitioning in bacteria[J]. Science, 2026, 392(6804): eaeb6410.前往小宇宙评论区与主播互动
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1490-芽孢杆菌代谢通量与蛋白质组配分脱钩机制
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