1491-Glutaminergic Neuromodulation of Skin Aging

This research identifies a critical connection between peripheral nerves and skin aging, revealing that glutamatergic neurons directly regulate the health of the dermis. The study demonstrates that a decline in neurofilament heavy chain (Nefh) within these nerves leads to reduced glutamate release, which subsequently triggers fibroblast senescence and a loss of collagen. Scientists discovered that the Nefh-Cdk5 axis is the essential mechanism governing this neurotransmitter activity, while the transporter Slc1a3 allows skin fibroblasts to receive anti-aging signals. Experimental results show that glutamate supplementation can effectively reverse skin aging symptoms by restoring collagen production and preventing cellular decay. Ultimately, these findings establish neuromodulation as a promising therapeutic frontier for treating age-related skin disorders and fibrosis.References:Wang Z, Jin X, Wu Y, et al. Skin-innervating glutamatergic neurons modulate aging[J]. Cell, 2026.前往小宇宙评论区与主播互动