1493-ULTRA: Rapid AI-Driven 3D Histology

The paper introduce ULTRA, a groundbreaking medical imaging platform that utilizes artificial intelligence and stimulated Raman scattering microscopy to perform high-speed 3D histology. This technology drastically reduces the time required for volumetric tissue analysis from several days to under 30 minutes, making it suitable for use during active surgeries. By employing a unique one-step clearing protocol and self-supervised deep learning, the system generates high-resolution, stain-free virtual histology that is comparable to traditional laboratory standards. Researchers successfully utilized ULTRA to map the three-dimensional boundaries of brain tumors and identify specific cellular heterogeneity that 2D methods often overlook. Ultimately, the sources highlight how this nondestructive approach assists surgeons in making more informed intraoperative decisions while preserving tissue for future molecular testing.References:Liu Z, Li Y, Chen L, et al. Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration[J]. Cell, 2026.前往小宇宙评论区与主播互动