EPISODE · Aug 26, 2026 · 20 MIN
1493-ULTRA：人工智能驱动的极速3D组织病理成像
from 聊聊Sci
本文介绍了一种名为 ULTRA 的创新型 3D 组织学成像平台，旨在攻克传统活检技术在手术期间处理速度慢、维度受限的问题。该技术巧妙结合了基于 AI 算法的图像优化与一种新型的快速透明化方案，能在 30 分钟内生成达到临床诊断级别的三维虚拟病理图像。研究表明，通过诱导细胞膜紊乱和使用氘代二甲基亚砜，该系统可实现毫米级深度的无标记高清成像。这项成果不仅能精准勾勒出胶质瘤在空间上的浸润边界，还能揭示肿瘤内部的细胞异质性，从而提升手术切除的精确度。作为一种无损检测手段，ULTRA 在显著缩短诊断周期的同时，还完整保留了组织样本以供后续的分子病理分析。因此，该平台为神经外科手术提供了实时的体积化视图，填补了术中快速三维组织成像的临床空白。References:Liu Z, Li Y, Chen L, et al. Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration[J]. Cell, 2026.前往小宇宙评论区与主播互动
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