EPISODE · Aug 26, 2026 · 16 MIN
1494-病毒组规模遗传筛选：ORF库系统解析宿主-病原体相互作用
from 聊聊Sci
这篇研究介绍了一个包含约1.3万个带条形码的病毒开放阅读框（vORF）库，旨在对跨越500多种病毒的蛋白质功能进行系统性遗传筛选。研究人员利用该平台识别出700多个影响细胞增殖、MHC I类分子抗原呈递及干扰素信信号传导的病毒调节因子。通过深入分析，该团队发现了两种新型免疫逃逸蛋白：MC162R通过降解MHC I类分子干扰抗原呈递，而YLDV 151R则通过抑制IRF9来阻断干扰素反应。该资源为探索病毒与宿主相互作用提供了可扩展的框架，并能揭示具有人畜共患风险的病毒进化机制。这项工作标志着从单病毒研究向全病毒组规模系统生物学研究的重大转变。References:Fujimura E, O’Leary C N, Li M Z, et al. A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1494-病毒组规模遗传筛选：ORF库系统解析宿主-病原体相互作用
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