EPISODE · Aug 27, 2026 · 16 MIN
1496-VIDA：基于病毒蛋白酶触发细胞裂解的通用型mRNA抗病毒疗法
from 聊聊Sci
该研究介绍了一种名为 VIDA 的创新型通用抗病毒 mRNA 疗法，其核心机制是利用病毒蛋白酶触发受感染细胞的裂解性死亡。研究人员通过基因工程改造微管蛋白 (GSDM)，将其内部的天然切割位点替换为特定病毒的蛋白酶识别序列，从而使药物仅在病毒存在时才会被激活。这种“杀伤并预警”的策略不仅能精准清除被感染的细胞，还能释放免疫信号以激活机体的保护性免疫反应。实验证明，该平台在应对甲肝病毒 (HAV)、寨卡病毒 (ZIKV) 以及 新冠病毒 (SARS-CoV-2) 等多种病毒时表现出显著的有效性。此外，团队还引入了生成式人工智能 (AI) 来优化设计，进一步提升了该疗法的安全性和抗病毒效能。References:Li L, Yan X L, Wang H Y, et al. Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1496-VIDA：基于病毒蛋白酶触发细胞裂解的通用型mRNA抗病毒疗法
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