15. What Causes Autoimmunity? A Deep Dive into Viruses, Inflammation, and Aging with Dr. Jessica Lasky Su

Hey friends, what if we stopped fighting over labels and actually started treating the mechanisms behind what's making people sick? That's the question driving today's conversation with Dr. Jessica Lasky-Su from Harvard Medical School and Brigham and Women's Hospital.Here's the thing. Her team is working at the edge of some really fascinating science, genetics, epigenetics, proteomics, metabolomics, antibody profiling. And what we dig into is how long COVID research, viral exposures, and autoimmunity all connect. This isn't just academic, right? This shift in thinking could change how we approach everything from chronic fatigue to neurodegeneration.We unpack the NIH's massive long COVID program. We're talking tens of thousands of participants, deep biospecimen collection, repeated measures over time, and patient advocates actually shaping what gets studied. The goal isn't some single tidy definition of long COVID. It's mapping out subtypes and mechanisms. Immune dysregulation, viral persistence, autonomic dysfunction, coagulation issues, mitochondrial strain. Once you define the mechanisms, drug repurposing becomes a real lever. You can match known compounds to pathways for faster trials and earlier relief for patients.Then we zoom out a bit. Research grade antibody profiling can detect tens of thousands of potential autoantibodies, way beyond what routine panels show. Some of these signals correlate strongly with diseases like Parkinson's and Alzheimer's, hinting at early warning markers or maybe even direct roles in the disease process itself. Molecular mimicry explains how infections, especially persistent herpesviruses like HSV-1, EBV, CMV, and VZV, can trigger immune misfires that target our own tissues. It's good intentions gone wrong at the cellular level, and it's why mechanisms matter more than the names we slap on things.We keep it practical too. Support immune balance with sleep, nutrition, movement, vitamin D optimization, stress regulation, gut health. If reactivation is suspected, talk to your clinician about antiviral strategies and stepped, mechanism aware care. This isn't hype. It's a grounded path from lab to life where functional medicine and rigorous research meet to shorten the distance between discovery and relief.If this conversation resonates, subscribe, share it with someone who needs clarity, and leave a review to help others find the show. Your questions shape what we explore next.That my friends, is the reality of medicine as I see it. Let's get real and get results.Ready to stop guessing and finally get a clear plan?Join Dr. Su for the Ask Dr. Mark Clinical Q&A Call, a small-group call limited to about five people each month where you can bring your real questions and get real direction.Book your spot: https://go.rootseekhealth.com/askdrmarkOr download the free Lab Results Guide if you have ever been told your labs are normal while still feeling terrible: https://labsoptin.rootseekhealth.com/labs/Connect with Dr. Su: IG | @rootseekhealthDisclaimer: This podcast is for educational purposes only.  Information discussed is not intended for diagnosis, curing, or prevention of any disease and is not intended to replace advice given by a licensed healthcare practitioner. This podcast and its guests may have direct or indirect financial interests associated with products mentioned.