EPISODE · Aug 28, 2026 · 22 MIN
1501-CRISPR筛选鉴定挽救癌症相关T细胞功能障碍靶点
from 聊聊Sci
这些研究揭示了 Dusp5 和 Zfp219 是导致老年个体中 T 细胞功能障碍的关键调节因子。科研人员利用 CRISPR 筛选技术发现，敲除这两个基因可以显著增强 CD8+ T 细胞在衰老肿瘤环境中的抗癌效能。Dusp5 的缺失通过激活 ERK 信号通路促进 T 细胞的大量增殖，而移除 Zfp219 则能通过重塑表观遗传景观来恢复细胞毒性分子的表达。这种干预手段不仅提高了老年小鼠的肿瘤控制率，还展现了与免疫检查点抑制剂协同工作的潜力。该发现为开发针对高龄癌症患者的免疫修复疗法提供了重要靶点。其研究结果进一步证实，ZNF219 在人体内的水平随年龄增长而升高，且能有效预测免疫治疗的预后效果。References:Chen A C Y, Ji K Y, Yerinde C, et al. CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1501-CRISPR筛选鉴定挽救癌症相关T细胞功能障碍靶点
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