EPISODE · Aug 28, 2026 · 16 MIN
1502-乳桥蛋白通过调控肠道菌群增强呼吸道免疫
from 聊聊Sci
这份研究揭示了母乳中的骨桥蛋白（OPN）如何通过调控肠道微生物群来保护新生儿免受严重的下呼吸道感染。实验表明，缺乏这种蛋白会导致幼鼠呼吸道中的树突状细胞（DC）发育不足，从而增加患肺炎的风险。通过补充乳酸杆菌产生的代谢物3-苯基乳酸（PLA），可以激活肺部的免疫发育路径。这种机制促进了造血祖细胞从肝脏迁移至肺部，并建立起关键的免疫耐受屏障。该发现不仅阐明了母乳增强婴儿免疫力的具体过程，也为通过代谢物干预预防幼儿肺部疾病提供了新思路。References:Howard D R, Rashid R B, Ahmed T, et al. Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1502-乳桥蛋白通过调控肠道菌群增强呼吸道免疫
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