EPISODE · Aug 28, 2026 · 22 MIN
1504-靶向外周5-HT2AR增强结直肠癌抗肿瘤免疫
from 聊聊Sci
这篇研究揭示了外周5-HT2AR受体在调节结直肠癌免疫反应中的关键作用。研究人员发现，经典致幻剂LSD能通过激活该受体增强CD8+ T细胞的抗肿瘤能力，但其致幻副作用限制了临床应用。为此，团队开发了不进入大脑的新型激动剂IHCH-8110，它能特异性激活肠道内的肠胶质细胞。这种激活促使细胞释放CXCL10和IL-18，从而招募并极化T细胞以攻击肿瘤。该化合物不仅能抑制癌症生长，还能使原本对免疫治疗不敏感的“冷肿瘤”产生反应，显著提升PD-1抑制剂的疗效。这一成果为结直肠癌的联合免疫治疗提供了无致幻风险的新策略。References:Wen Y T, Tang L J, Duan W W, et al. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1504-靶向外周5-HT2AR增强结直肠癌抗肿瘤免疫
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