1504-Targeting 5-HT2AR to Enhance Antitumor Immunity in CRC

This research article explores how activating the 5-HT2AR serotonin receptor can significantly enhance antitumor immunity in colorectal cancer. The study identifies that while LSD suppresses tumor growth, its use is limited by psychedelic effects caused by brain penetration. To overcome this, researchers developed IHCH-8110, a specialized non-brain-penetrant agonist that selectively targets receptors in the peripheral nervous system. This compound works by activating enteric glial cells, which then release specific cytokines to recruit and empower CD8+ T cells within the tumor. Notably, this treatment can transform "immune-cold" tumors into responsive ones, markedly increasing the effectiveness of anti-PD-1 immunotherapy. Ultimately, the findings suggest that targeting the enteric nervous system provides a promising, hallucination-free strategy for treating advanced colorectal cancer.References:Wen Y T, Tang L J, Duan W W, et al. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer[J]. Cell, 2026.前往小宇宙评论区与主播互动