EPISODE · Aug 29, 2026 · 25 MIN
1509-代谢调节人类皮质细胞命运图谱
from 聊聊Sci
这份研究报告详细绘制了早期人类大脑皮层及类器官的代谢图谱。科学家们发现，葡萄糖的供应情况能显著影响放射状胶质细胞的命运走向。研究重点指出，磷酸戊糖途径在调节细胞转型中起到了关键作用。通过药物或基因手段抑制该代谢途径，会导致神经元和外放射状胶质细胞的数量发生改变。令人关注的是，补充核糖可以有效修复因代谢受阻而产生的基因表达异常，并恢复细胞的正常比例。总之，该研究揭示了能量代谢如何决定大脑发育过程中关键细胞类型的生成。References:Mil J, Soto J A, Krall A S, et al. Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions[J]. Cell, 2026.前往小宇宙评论区与主播互动
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