EPISODE · Aug 30, 2026 · 19 MIN
1514-端粒缩短通过sDLK1诱导脑衰老与功能障碍
from 聊聊Sci
这项研究揭示了端粒缩短驱动大脑衰老的分子机制。研究发现，端粒受损会诱发小胶质细胞衰老，使其分泌出一种名为 sDLK1 的有害信号因子。这种因子在老年小鼠的脑脊液中显著升高，并被证实是导致髓鞘发育不良和神经元功能障碍的关键诱因。通过在人类诱导多能干细胞模型中进行实验，研究者进一步确认 sDLK1 会阻碍少突胶质细胞的成熟并干扰神经元的钙信号处理。该成果确立了衰老的小胶质细胞与大脑白质退化及认知衰退之间的直接联系，为理解病理性大脑衰老提供了全新的视角。References:Liu B, Mahoney M, Feng Y, et al. Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction[J]. Neuron, 2026.前往小宇宙评论区与主播互动
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1514-端粒缩短通过sDLK1诱导脑衰老与功能障碍
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