EPISODE · Aug 31, 2026 · 16 MIN
1520-脐血DN NK细胞亚群清除提升CAR-NK疗效
from 聊聊Sci
这项研究揭示了脐带血中一种未成熟的双阴性（DN）NK细胞亚群如何损害 CAR NK 细胞疗法的疗效。研究发现，这种 DN 亚群在工程化后表现出极强的胞吞作用，通过从肿瘤细胞摄取抗原形成了“抗原汇（TAS）”，进而诱发对正常效应细胞的兄弟残杀及功能耗竭。与之相反，双阳性（DP）亚群展现出更强的杀伤力和临床相关性。作者提出，在制造过程中剔除 DN 细胞或采用逻辑门控 CAR 设计，可以有效阻断这种由抗原重新分布引起的失能。这一发现为优化现货型 CAR NK 疗法的捐献者筛选与生产工艺提供了关键的理论支持和实践策略。References:Li Y, Fan H, Wang G, et al. Depletion of an immature cord blood NK subset reverses trogocytosis-driven CAR NK dysfunction[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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1520-脐血DN NK细胞亚群清除提升CAR-NK疗效
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