EPISODE · Sep 1, 2026 · 25 MIN
1521-PD-1阻断后的肿瘤特异性抗体发现与应用
from 聊聊Sci
这份研究报告探讨了在非小细胞肺癌患者接受PD-1抑制剂治疗后，其肿瘤组织内浆细胞的免疫反应。研究人员利用单细胞测序技术从这些浆细胞中提取并合成了多种单克隆抗体，其中领先的抗体PC-1表现出卓越的抗肿瘤潜力。实验证明，PC-1能精确识别肿瘤细胞及促癌髓系细胞表面因瓜氨酸化而产生的特异性抗原。以此抗体为基础开发的CAR-T细胞疗法在动物实验中成功清除了癌细胞，且未产生明显的脱靶毒性。该成果揭示了挖掘肿瘤内源性体液免疫资源在开发新一代癌症免疫疗法中的关键价值。References:Meyerhoff R R, Chen A, O’Brien J, et al. Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies[J]. Cancer Cell, 2026.前往小宇宙评论区与主播互动
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1521-PD-1阻断后的肿瘤特异性抗体发现与应用
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