EPISODE · Sep 1, 2026 · 19 MIN
1523-骨髓微环境中介导免疫应答的潜伏效应T细胞
from 聊聊Sci
这篇研究探讨了多发性骨髓瘤 (MM)与急性髓系白血病 (AML)患者骨髓环境中的肿瘤反应性T细胞。研究通过单细胞测序与功能筛选发现，这些T细胞表现出一种独特的潜伏效应状态，明显区别于实体瘤中常见的耗竭表型。作者揭示了这些血液恶性肿瘤主要由非规范来源的抗原驱动，而非传统的体细胞突变，并识别出可跨患者共享的免疫攻击靶点。基于这些特征，研究团队开发了名为 TFiT 的转录组分类器，能够有效预测患者对免疫治疗（而非化疗）的反应。该发现证实了骨髓癌症中存在可被重新激活的抗肿瘤免疫潜力，为开发新型免疫疗法提供了关键的理论框架。References:Kehl N, Wagner T R, Steiger S, et al. Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment[J]. Cancer cell, 2026.前往小宇宙评论区与主播互动
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1523-骨髓微环境中介导免疫应答的潜伏效应T细胞
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