EPISODE · Sep 1, 2026 · 21 MIN
1525-人类伏隔核空间分子图谱
from 聊聊Sci
这份研究通过整合单细胞核RNA测序 (snRNA-seq)与空间转录组学 (SRT)技术，构建了人类伏隔核 (NAc)的高分辨率空间分子图谱。研究者发现，伏隔核内的中型多棘神经元 (MSN)并非离散分布，而是以连续的转录梯度跨越解剖区域，并识别出富含OPRM1基因且具有进化保守性的D1岛。通过跨物种比较与迁移学习，该研究定位了与神经精神疾病风险及药物反应（如吗啡和可卡因）相关的特定细胞群体与空间结构。此外，研究还揭示了介导成瘾和压力反应的配体-受体相互作用在空间上的分布规律。总之，该成果为理解人类奖励电路的分子特性、解剖组织及其在精神疾病和物质依赖中的作用提供了关键的系统框架。References:Ravichandran P, Bach S V, Phillips R A, et al. Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens[J]. Neuron, 2026.前往小宇宙评论区与主播互动
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1525-人类伏隔核空间分子图谱
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