EPISODE · Sep 2, 2026 · 23 MIN
1529-控制强迫性进食的大脑皮层-下丘脑回路
from 聊聊Sci
这项研究揭示了一个名为mPFC-rZI的脑部回路，它是驱动强迫性进食的关键机制。通过对小鼠的实验发现，大脑前额叶皮层（mPFC）会向下丘脑的不定带（ZI）发送信号，即使在面对电击或苦味食物等负面后果时，该通路依然能维持进食冲动。研究人员利用光遗传学和化学遗传学技术证实，激活这一回路会诱发暴饮暴食，而抑制它则能有效减少强迫性摄食行为。此外，人类功能磁共振成像（fMRI）数据显示，该神经回路的连接强度与肥胖、暴食症以及体质量指数（BMI）密切相关。这项跨物种的研究不仅发现了病理性进食的神经动力学特征，还为治疗暴食症和肥胖提供了潜在的临床靶点。References:Leow Y N, Senol E, Qian X, et al. A cortical-hypothalamic neural circuit for compulsive eating in mice[J]. Neuron, 2026.前往小宇宙评论区与主播互动
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1529-控制强迫性进食的大脑皮层-下丘脑回路
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