EPISODE · Sep 4, 2026 · 14 MIN
1536-原核生物STAND受体对噬菌体蛋白质的模式识别
from 聊聊Sci
这项研究通过对原核生物 STAND NTPase 超家族的系统发育分析，揭示了细菌免疫中一种基于结构的病原体识别机制。研究人员鉴定出 90 多个与抗病毒防御相关的结构独特家族，并重点解析了 Avs7 家族如何识别噬菌体的主要衣壳蛋白（MCP）。实验表明，Avs7 在感知 MCP 后会发生构象变化并组装成不对称的四聚体，同时募集宿主因子 EF-Tu 来增强其核酸酶活性。此外，研究还发现另外 13 个 STAND 家族能够感应包括 DNA 聚合酶和尾部组件在内的多种核心噬菌体蛋白。这些发现证明了蛋白质折叠识别和宿主因子重用是细菌防御系统中普遍存在的策略。该研究为理解细菌如何通过精细的结构监测来对抗病毒感染提供了重要的分子基础。References:Lee H, Luengo-Woods S, Zhang J, et al. Diverse bacterial pattern recognition receptors sense the conserved phage proteome[J]. bioRxiv, 2026.前往小宇宙评论区与主播互动
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1536-原核生物STAND受体对噬菌体蛋白质的模式识别
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