EPISODE · Sep 4, 2026 · 18 MIN
1539-星形胶质细胞驱动中枢神经系统自身免疫
from 聊聊Sci
这项研究揭示了星形胶质细胞在驱动多发性硬化症（MS）及其动物模型中的关键作用。通过使用RABID-seq和单细胞测序等先进技术，研究人员发现了一群表达CD40和MHC-II分子的特殊星形胶质细胞，它们能够充当“非职业性”抗原递呈细胞。这些细胞通过与CD4+ T细胞直接互动，显著增强了致病性TH17细胞的免疫反应，从而加剧了中枢神经系统的自身免疫炎症。此外，研究还阐明了CD40信号通路如何通过诱导脂滴堆积来促进炎症因子的产生。这一发现不仅定义了一种此前未被识别的免疫调节机制，也为治疗中枢神经系统自身免疫疾病提供了新的潜在靶点。References:Lee J H, Li Z, Soto J S, et al. Antigen presentation by CD40+ MHC-II+ astrocytes promotes CNS autoimmunity[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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1539-星形胶质细胞驱动中枢神经系统自身免疫
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