EPISODE · Sep 8, 2026 · 24 MIN
1556-SecAct：细胞间通讯中分泌蛋白信号活性的推断框架
from 聊聊Sci
这篇论文介绍了一种名为 SecAct 的创新计算框架，旨在推断人类基因组中 1,170 种分泌蛋白的信号传导活性。研究人员利用涵盖 37 种癌症类型的 1,258 份空间转录组样本，通过分析蛋白质与其功能靶基因之间的空间相关性，构建了高置信度的活性特征库。该工具能够处理单细胞、空间及大块转录组数据，克服了以往方法在覆盖范围和生理相关性上的局限。通过分析 54 个癌症免疫治疗队列，SecAct 成功识别出与肿瘤免疫相关的关键蛋白，并实验验证了 LY86 分子的抗肿瘤调节功能。此外，该研究还提供了在线交互平台，用于探索复杂的细胞间通讯模式和临床预后关联。References:Ru B, Gong L, Yang E, et al. Inference of secreted protein signaling activities in intercellular communication[J]. Nature methods, 2026: 1-11.前往小宇宙评论区与主播互动
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1556-SecAct：细胞间通讯中分泌蛋白信号活性的推断框架
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