EPISODE · Sep 8, 2026 · 26 MIN
1557-可逆性胚表层区域化决定人类多能干细胞分化潜能
from 聊聊Sci
这项研究揭示了人类多能干细胞（hPSCs）在体外分化过程中出现效能差异的分子机制。研究发现，分化能力受损的干细胞系往往处于一种后部外胚层样状态，其特征是关键发育基因位点的二价染色质修饰发生侵蚀，导致发育基因提前表达并丧失神经分化潜能。为了克服这一障碍，研究人员开发了一种名为化学染色质修复（CHR）的转基因技术，通过调节组蛋白修饰来重塑基因组景观。实验证明，该方法能成功将受损细胞恢复到具有前部竞争性的状态，使其重新获得产生三种胚层组织的能力。这一发现为疾病建模和再生医学中高质量干细胞系的筛选与修复提供了关键的理论依据和实践路径。References:Sutcliffe M A, Wong E, Wingett S W, et al. Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells[J]. Nature Biotechnology, 2026: 1-13.前往小宇宙评论区与主播互动
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1557-可逆性胚表层区域化决定人类多能干细胞分化潜能
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