EPISODE · Sep 8, 2026 · 30 MIN
1558-基质细胞衰老增强克隆性造血中的细胞适性
from 聊聊Sci
该研究通过单细胞转录组测序等技术，揭示了在克隆性造血过程中，突变造血细胞会通过分泌细胞因子诱导骨髓中的间充质基质细胞（MSCs）发生细胞衰老。这种微环境的改变不仅赋予了突变细胞更强的竞争优势，还促进了疾病向骨髓恶性肿瘤的演变。研究发现，这种衰老现象广泛存在于携带不同基因突变的小鼠模型和人类患者中。实验进一步证明，通过遗传手段或药物干预清除衰老细胞，可以有效降低突变克隆负荷并延缓癌症进程。这些成果为通过阻断造血细胞与微环境之间的相互作用来预防血液癌症提供了全新的策略。References:Mistry J J, Young K A, Navarro Figueredo A, et al. Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis[J]. Nature Cell Biology, 2026: 1-15.前往小宇宙评论区与主播互动
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1558-基质细胞衰老增强克隆性造血中的细胞适性
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