1560-ULTRA: AI-Driven 3D Histology for Glioma Mapping

1 source·Aug 27, 2026This research introduces ULTRA, a novel medical imaging platform that revolutionizes pathology by delivering three-dimensional virtual histology in less than 30 minutes. By combining a one-step tissue-clearing protocol with advanced artificial intelligence, the system enables surgeons to visualize tumor margins and cellular architecture at an intraoperative timescale. The method utilizes stimulated Raman scattering (SRS) microscopy to achieve chemical specificity without the need for traditional slides, stains, or fixatives. This technological leap addresses the limitations of standard 2D biopsies, which often suffer from sampling bias and slow processing times. Ultimately, ULTRA facilitates more precise surgical decision-making by identifying glioma infiltration and tumor heterogeneity with single-cell resolution.References:Liu Z, Li Y, Chen L, et al. Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration[J]. Cell, 2026.前往小宇宙评论区与主播互动