1563-Metabolic Atlas of Human Cortical Development

This paper presents a comprehensive metabolic map of the developing human brain, focusing on how nutrient processing influences the maturation of various brain cells. The research highlights two specific chemical pathways, glycolysis and the pentose phosphate pathway, as essential drivers for the transformation of radial glia into specialized neural populations. By experimenting with cortical organoids, the authors discovered that altering glucose access or inhibiting key enzymes directly changes the ratio of different cell types produced. Notably, the study found that ribose could counteract the negative effects of pathway inhibition, restoring normal gene expression and energy levels. Ultimately, these findings reveal that metabolic states are not just results of growth but are active regulators that determine the final cellular architecture of the human cortex.References:Mil J, Soto J A, Krall A S, et al. Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions[J]. Cell, 2026.前往小宇宙评论区与主播互动