EPISODE · Sep 10, 2026 · 27 MIN
1563-人类皮质发育代谢图谱与细胞命运调控
from 聊聊Sci
这项研究展示了人类早期大脑皮层发育的代谢图谱，重点探讨了营养代谢如何决定细胞的演变过程。研究人员发现，葡萄糖的供应量以及糖酵解过程能显著影响皮层细胞的最终形态。特别是磷酸戊糖途径（PPP）在调节径向胶质细胞的命运中起到了关键作用。通过对类器官进行实验，科学家证实代谢失衡会导致细胞比例发生改变，而补充核糖则能修复这些基因表达及细胞类型的偏差。总而言之，该成果揭示了能量代谢途径在人类大脑神经发生过程中的核心调控地位。References:Mil J, Soto J A, Krall A S, et al. Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions[J]. Cell, 2026.前往小宇宙评论区与主播互动
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