EPISODE · Sep 10, 2026 · 31 MIN
1564-肠道肌肉的性别与生殖可塑性控制肠道大小
from 聊聊Sci
这项研究揭示了肠道肌肉在调节成体器官大小和功能方面发挥着主动且关键的作用，而非仅仅是被动受累。通过对果蝇和小鼠的观察，科学家发现雌性个体的肠道肌肉在繁殖期间会经历显著的分子与结构重塑，这种现象被称为生殖可塑性。在果蝇实验中，研究者证实了肌肉内部的性别决定因子直接影响肌原纤维的粗细，从而从外部决定了整个肠道的基准尺寸。此外，生殖过程中的激素变化会促使雌性果蝇的肌节伸长，这一生理变化能有效减缓肠道蠕动，进而促进营养吸收并提升繁殖能力。该成果打破了以往认为肠道改变仅由上皮干细胞驱动的观点，证明了内脏肌肉是器官适应环境挑战和生理需求的核心调节者。References:Mineo A, Blackie L, Milona A, et al. The sex and reproductive plasticity of intestinal muscles instruct gut size[J]. Cell, 2026.前往小宇宙评论区与主播互动
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