EPISODE · Sep 11, 2026 · 17 MIN
1566-成年猕猴全生命周期多模态脑细胞图谱
from 聊聊Sci
这份研究通过构建单细胞多组学图谱，详细揭示了非人灵长类动物（食蟹猴）大脑随年龄增长的演变过程。科研人员分析了覆盖多个脑区的近三百万个细胞核，深入探讨了基因表达、染色质重塑以及细胞间通讯的动态变化。研究指出，不同脑区和细胞类型在衰老过程中表现出特异性的脆弱性，并揭示了神经元与胶质细胞之间交互信号的减弱。通过跨物种对比，该成果阐明了灵长类动物在神经元衰老方面的保守性，同时识别出与阿尔茨海默病等退行性疾病相关的差异性特征。此外，针对长寿个体的分析发现，特定的基因调控机制可能在极端高龄时起到神经保护作用。这项工作为理解灵长类大脑的退化机制及寻找延缓衰老的潜在干预靶点提供了宝贵的数据支持。References:Zhang X, Lai G, Guo X, et al. Multimodal brain cell atlas across the adult macaque lifespan[J]. Cell, 2025.前往小宇宙评论区与主播互动
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1566-成年猕猴全生命周期多模态脑细胞图谱
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