1566-Multimodal Brain Cell Atlas of Adult Macaque Lifespan

This study presents a comprehensive single-cell multi-omic atlas documenting the aging process within the brains of non-human primates. Researchers analyzed over 1.4 million nuclei from various brain regions in macaques to track changes in gene expression and chromatin accessibility across their lifespan. The findings highlight how specific neuronal and glial cell types exhibit different vulnerabilities, including altered synaptic signaling and neuroinflammatory responses. Notably, the research identifies conserved aging patterns shared between macaques and humans while also noting divergent paths in neurodegenerative diseases like Alzheimer’s. Additionally, the data suggests that exceptionally old individuals may possess unique aging-protective effects linked to specific genomic regulatory elements. Ultimately, this multimodal atlas serves as a foundational resource for understanding the biological mechanisms of primate brain senescence.References:Zhang X, Lai G, Guo X, et al. Multimodal brain cell atlas across the adult macaque lifespan[J]. Cell, 2025.前往小宇宙评论区与主播互动