EPISODE · Sep 11, 2026 · 18 MIN
1567-诺如病毒RNA结构图谱与疫苗减毒策略研究
from 聊聊Sci
这项研究通过化学探针技术首次绘制了小鼠诺如病毒（MNV）的完整全基因组RNA二级结构图谱。研究人员在编码区内鉴定了16个高度稳定的静态结构区域，并证实这些结构在不同诺如病毒株中具有进化保守性。实验表明，干扰这些特定结构（如lowSS1和lowSS10）能显著抑制病毒的蛋白质翻译与复制能力。利用这一特性，科学家通过同义突变人工构建了结构减毒病毒，使其在保持蛋白质序列完整的前提下降低毒性。这种减毒病毒在动物实验中表现出极高的遗传稳定性，并能诱导产生强效的保护性免疫应答。该成果为开发针对诺如病毒及其他RNA病毒的理性设计疫苗提供了全新的技术框架。References:Hann T, Ökten A B, Filler R B, et al. RNA structures regulate norovirus life cycle and enable rational attenuation in vivo[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1567-诺如病毒RNA结构图谱与疫苗减毒策略研究
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