EPISODE · Sep 12, 2026 · 24 MIN
1569-cMAF调控脑血管周围巨噬细胞及其功能的分子机制
from 聊聊Sci
这项研究揭示了cMAF转录因子在维持大脑健康及预防疾病中的核心作用。研究通过小鼠实验与人类数据分析发现，cMAF是脑周血管巨噬细胞（PVMs）的关键调控因子，负责维持这些细胞的身份特征。具体而言，cMAF驱动巨噬细胞产生胰岛素样生长因子-1（IGF1），进而与血管内皮细胞进行分子对话，确保脑脊液流动和脑血流调节的正常运作。若缺失该蛋白，血管功能将受损，进而影响大脑代谢环境。此外，研究指出该转录程序在人类中高度保守，且cMAF表达的增加与阿兹海默症风险降低相关。这一发现为针对神经退行性疾病和脑血管病变的治疗策略提供了新方向。References:Brioschi S, Belk J A, Storck S E, et al. Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1569-cMAF调控脑血管周围巨噬细胞及其功能的分子机制
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