EPISODE · Sep 12, 2026 · 18 MIN
1570-肠道微生物转化硝酸盐产生心血管获益
from 聊聊Sci
这是一项关于肠道微生物如何通过转化饮食中的硝酸盐和非血红素铁来生成二亚硝基铁配合物（DNICs）的研究。研究发现，这些由细菌产生的配合物具有全身性生物活性，且其发挥作用并不依赖于游离的一氧化氮。通过在动物模型和人类肝细胞实验中进行验证，DNICs 被证明能显著改善代谢综合征，并有效预防脂肪肝。其核心机制在于激活 sGC-cGMP 通路并抑制亮氨酸吸收，从而调节失衡的 mTORC1 信号以维持代谢健康。这一发现揭示了饮食成分与肠道菌群相互作用对心血管及代谢保护的新路径。References:Kleschyov A L, Shimari M, Boeder A M, et al. Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1570-肠道微生物转化硝酸盐产生心血管获益
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