EPISODE · Sep 13, 2026 · 27 MIN
1571-空间多组学联测：3D基因组与转录组绘图
from 聊聊Sci
这份名为“Spatial Hi-C-RNA”的研究介绍了一种创新的多组学技术平台，能够同时在完整组织切片中绘制三维基因组结构与全转录组图谱。该技术结合了微流控空间条形码、Hi-C 染色质捕捉和 RNA 测序，旨在揭示基因组三维折叠如何跨空间维度调控基因表达。通过对成年小鼠大脑、胚胎发育以及人类黑色素瘤的应用研究，科学家们发现染色质的物理形态与细胞身份及空间定位高度相关。研究结果表明，这种整合方法能识别出仅靠转录组无法发现的肿瘤内部异质性，并揭示了神经发育过程中基因组结构的动态重塑。总之，该技术为在生理和病理背景下深入理解基因组结构与功能之间的关系提供了强有力的工具。References:Guo P, Cui Y, He J, et al. Integrative spatial profiling of 3D genome organization and gene expression in tissue[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1571-空间多组学联测：3D基因组与转录组绘图
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