EPISODE · Sep 13, 2026 · 29 MIN
1572-靶向外周5-HT2AR增强结直肠癌抗肿瘤免疫
from 聊聊Sci
这项研究揭示了外周血清素受体 5-HT2AR 在调控结直肠癌抗肿瘤免疫中的新机制。研究人员发现，虽然传统幻觉剂 LSD 能抑制肿瘤生长，但其成瘾和致幻副作用限制了临床应用。为此，团队开发了名为 IHCH-8110 的新型激动剂，该药物不进入大脑，从而在避免幻觉效果的同时，专一激活肠道中的肠神经胶质细胞。这种激活促使胶质细胞释放关键细胞因子，进而招募并增强 CD8+ T细胞 对肿瘤的杀伤能力。实验证明，该疗法能显著提升免疫检查点阻断（如 PD-1 抗体）的疗效，为治疗对免疫疗法不敏感的“冷肿瘤”提供了全新的策略。References:Wen Y T, Tang L J, Duan W W, et al. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1572-靶向外周5-HT2AR增强结直肠癌抗肿瘤免疫
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