EPISODE · Sep 13, 2026 · 17 MIN
1573-乳源骨桥蛋白调节肠道菌群与免疫发育
from 聊聊Sci
该研究阐明了母乳中的骨桥蛋白（OPN）如何通过调控肠道微生物群来保护婴儿免受严重下呼吸道感染。实验表明，缺乏母乳OPN会导致新生小鼠的乳杆菌科丰度降低，进而减少血清中代谢物3-苯基乳酸（PLA）的含量。这种代谢缺失会损害肝脏和肺部的树突状细胞（DC）造血功能，使机体对病毒和细菌感染失去免疫耐受。通过补充PLA或激活PPARγ受体，可以诱导肺上皮细胞表达CCL25和Flt3L，从而招募免疫祖细胞并重建呼吸道的免疫防御屏障。这一发现揭示了“肠-肺轴”在早期发育中的关键作用，为通过营养干预预防婴儿呼吸系统疾病提供了理论基础。References:Howard D R, Rashid R B, Ahmed T, et al. Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance[J]. Cell, 2026.前往小宇宙评论区与主播互动
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1573-乳源骨桥蛋白调节肠道菌群与免疫发育
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