EPISODE · Sep 15, 2026 · 15 MIN
1578-AGENTEX：自动化遗传密码原型设计与扩展
from 聊聊Sci
本文介绍了一种名为AGENTEX的自动化机器人平台，旨在通过无细胞翻译系统快速原型化并构建人工遗传密码。研究人员突破了长期以来认为tRNA末端必须为CCA序列才能被氨酰化的传统认知，发现大肠杆菌氨酰-tRNA合成酶能够灵活地为多种非标准末端（如CGA）的tRNA充电。利用这一发现，他们开发了tSCAN技术以自动监测氨酰化效率，并结合工程化核糖体实现了正交翻译，有效避免了与天然系统的交叉干扰。该系统成功实现了遗传密码的压缩与重分配，能够将非标准氨基酸单体引入多肽合成。这项成果不仅为生物聚合物的高效合成开辟了新途径，也深化了人类对翻译系统演化逻辑的理解。References:Radford F, Sapers N, Burgess H M, et al. Automated prototyping of genetic codes[J]. Nature, 2026: 1-11.前往小宇宙评论区与主播互动
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