EPISODE · Sep 15, 2026 · 15 MIN
1579-鼠耳蝠基因组：长寿、抗癌与病毒适应性的演化机制
from 聊聊Sci
这项研究通过对鼠耳蝠属（Myotis）八个物种的高质量基因组测序，揭示了其长寿、抗癌及病毒耐受性的遗传基础。研究发现，这些蝙蝠对DNA病毒和RNA病毒展现出截然不同的演化适应机制，例如免疫因子PKR在物种间存在古老的拷贝数变异。分析表明，鼠耳蝠在演化过程中经历了与癌症抑制和DNA损伤修复相关的基因正向选择，这解释了其远超同等体型哺乳动物的寿命。实验证明，长寿物种如小棕蝠具有更灵敏的细胞凋亡反应以清除受损细胞，体现了其在衰老与免疫上的协同演化。总之，这些数据为理解哺乳动物如何通过基因多效性实现疾病抵御与寿命延长提供了关键见解。References:Vazquez J M, Lauterbur M E, Mottaghinia S, et al. Insights into longevity and virus-driven adaptation from Myotis bat genomes[J]. Nature, 2026: 1-10.前往小宇宙评论区与主播互动
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1579-鼠耳蝠基因组：长寿、抗癌与病毒适应性的演化机制
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