1582-The Pan-Cancer Single-Cell Multimodal Regulatory Atlas

This research paper introduces a pan-cancer single-cell atlas that explores the gene regulatory networks of 60 human cancer cell lines through multimodal profiling. By integrating transcriptomic and chromatin accessibility data, the authors identify a universal epithelial-mesenchymal transition (EMT) axis that exists independently of a tumor's tissue of origin. The study highlights how copy-number variations, particularly transcription factor amplifications like CEBPB, act as primary drivers for reprogramming malignant cell states. Furthermore, the authors uncover a significant regulatory divergence between acral and cutaneous melanoma, revealing an inflammation-suppressive program unique to the rare acral subtype. These findings demonstrate that tumor-intrinsic regulation captured in vitro can effectively predict clinical microenvironmental compositions and patient responses to immunotherapy. Ultimately, this comprehensive resource provides a framework for mapping the regulatory logic that shapes cellular plasticity across diverse and rare cancers.References:Xu Z, Ugurbil A, Kwan J, et al. Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features[J]. Nature Communications, 2026, 17(1): 6975.前往小宇宙评论区与主播互动