EPISODE · Sep 17, 2026 · 20 MIN
1584-衰老诱导的基质硬化与胰腺癌化疗耐药性
from 聊聊Sci
这份研究揭示了胰腺导管腺癌（PDAC）在化疗后产生耐药性的核心机制。研究发现，吉西他滨化疗会诱导肿瘤细胞进入衰老状态，并通过分泌相关表型激活成纤维细胞，导致间质纤维化和硬度增加。这种物理环境的变化通过机械敏感通道 Piezo1 触发了细胞内的代谢重塑，并促使 BRG1 与 NRF2 结合，增强了肿瘤的抗氧化防御能力。这种适应性机制帮助肿瘤细胞逃避铁死亡，从而产生耐药。最终，研究证实通过结合衰老抑制剂与铁死亡诱导剂，可以有效拆解这种保护机制，显著抑制肿瘤生长并改善免疫微环境。References:Liu X, Huang Z, Yang B, et al. Chemotherapy-induced senescence promotes stroma stiffness and antioxidant adaptation to promote chemoresistance in pancreatic ductal adenocarcinoma[J]. Nature Communications, 2026, 17: 8798.前往小宇宙评论区与主播互动
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1584-衰老诱导的基质硬化与胰腺癌化疗耐药性
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