EPISODE · Sep 18, 2026 · 22 MIN
1587-双室脂质载体协同胞吐增强NK细胞抗肿瘤效能
from 聊聊Sci
这些研究介绍了一种新型的双室脂质纳米颗粒平台，旨在通过时空代谢重构增强过继性细胞疗法（如NK细胞、T细胞和巨噬细胞）对实体瘤的治疗效果。该系统利用脂质纳米颗粒递送NMN以修复免疫细胞内部的NAD⁺代谢，同时开发出内质网杂交脂质体，通过“劫持”细胞内的外排分泌路径将DCA精准释放至肿瘤区域。这种设计成功解决了肿瘤微环境中高浓度乳酸导致的免疫抑制难题，有效恢复了免疫细胞的细胞毒性功能并延长了其存活时间。实验数据证明，该疗法在骨肉瘤等多种实体瘤模型及患者来源的异种移植物（PDX）中均表现出显著的抑瘤活性和良好的安全性。总之，这项工作为克服实体瘤代谢屏障提供了一种极具潜力的普适性工程化策略。References:Chen S, Shao Z, Zhou Y, et al. Dual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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1587-双室脂质载体协同胞吐增强NK细胞抗肿瘤效能
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