159. Is MCAS or Histamine Intolerance Genetic?

Histamine and MCAS are everywhere on the internet right now, but there’s a huge piece missing from the conversation. Genetics. In this episode, I’m joined by two board-certified genetic counselors, Natalie Samson and Sarah Upp of Golden Genetics. They’re here to break down what’s going on at a DNA level when it comes to histamine intolerance, MCAS, connective tissue disorders, and the symptoms so many vestibular warriors are navigating. The biggest takeaway might just be how you can start advocating for yourself with your providers (especially if these things are new to them). This one is dense, practical, and unlike any conversation I’ve had on this podcast before. In this episode, we’ll dig into: How genetic changes affect how your body works How your environment and genetics work together The pentad super syndrome Why weak connective tissue may be at the root of these overlapping conditions What happens when the DAO and HMT genes aren’t working well Where histamine comes from and how to empty it The barn analogy for understanding mast cell stabilization Why a low histamine diet isn’t meant to be forever Foods to add in that lower histamine The two panels Golden Genetics recommends Why methylation matters for histamine breakdown What to do when testing for MCAS doesn’t give clear answers How to advocate for yourself when a provider dismisses MCAS as a social media diagnosis The ongoing research between Golden Genetics and the vestibular migraine community How to use the 2026 MCAS guidelines flowchart at your next appointment Histamine intolerance and MCAS aren’t just about what you’re eating. They’re rooted in your genetics, and understanding your specific DNA can help you stop guessing and start identifying the right interventions for your body. Related Episodes: Toxic Products That May Be Making Your Dizziness Worse w/ Dr. Zach Spiritos: https://thevertigodoctor.com/podcast/53-toxic-products-that-may-be-making-your-dizziness-worse/ Meet Natalie Samson & Sarah Upp Natalie Samson and Sarah Upp are both board-certified genetic counselors and the team behind Golden Genetics, an integrative genetic counseling practice. They specialize in helping people understand their DNA, order the right tests and turn results into a personalized action plan—with a special focus on histamine, inflammation, connective tissue, and nutrigenomics. Natalie founded Golden Genetics to bring genetics into the integrative health conversation, and together she and Sarah are currently conducting research on the genetic links to vestibular migraine. Connect w/ Natalie Samson & Sarah Upp: Website: www.goldengeneticshealth.com What is a logistics call with Golden Genetics? https://goldengenetics.practicebetter.io/#/652843bfc5600d631946d7b9/bookings?r=67d88822ff4b8cf37956c65d&step=services Book a logistics call with Golden Genetics: https://www.goldengeneticshealth.com/book-a-discovery-call-1 Pre-test session with Sarah: https://goldengenetics.practicebetter.io/#/687574970c2232e0dccceef5/bookings?r=69bb16570d392e7826c8903b Instagram: https://www.instagram.com/goldengeneticshealth Links Mentioned: Vestibular Group Fit (code GROUNDED at checkout for 15% off!): https://thevertigodoctor.com/vestibular-group-fit 2026 MCAS Guidelines flowchart: https://www.mastcellaction.org/assets/_/2025/04/01/d6de24e1-f6f6-4248-a3f4-12866d7bf713/mast-cell-activation-syndrome-mcas-a-primary-care-guide-final.pdf Free Resources: ⁠The 4 Steps to Managing Vestibular Migraine: https://thevertigodoctor.myflodesk.com/cb5js0y78n ⁠The PPPD Management Masterclass⁠: https://thevertigodoctor.myflodesk.com/new-pppd ⁠What your Partner Should Know About Living with Dizziness⁠: https://thevertigodoctor.myflodesk.com/partnership ⁠The FREE Mini VGFit Workout⁠: https://thevertigodoctor.myflodesk.com/minifit ⁠The FREE POTS – safe Workouts⁠: https://thevertigodoctor.myflodesk.com/pots Connect with Dr. Madison (@TheVertigoDoctor): https://instagram.com/thevertigodoctor Work with Dr. Madison: For 1:1 Vestibular Rehabilitation Therapy, email [email protected] Otherwise, I’ll see ya in Vestibular Group Fit! Connect with Dr. Jenna (@dizzy.rehab.therapist): https://www.instagram.com/dizzy.rehab.therapist/ Learn about the Oak Method: http://thevertigodoctor.com/why-vestibular-group-fit Love what you heard? Consider leaving a review on your favorite podcast platform to help us reach more vestibular warriors like you! This podcast is for informational purposes only and may not be the best fit for you and your personal situation. It shall not be construed as medical advice. The information and education provided here is not intended or implied to supplement or replace professional medical treatment, advice, and/or diagnosis. Always check with your own physician or medical professional before trying or implementing any information read here. is histamine intolerance genetic, genetics and mcas, genetics and histamine, genetic counselors, vestibular migraine, VM, chronic dizziness, PPPD, nervous system regulation, migraine management, vestibular group fit, VGF