EPISODE · Sep 19, 2026 · 20 MIN
1590-结直肠癌细胞转移中的伤口修复程序重塑
from 聊聊Sci
这项研究揭示了结直肠癌（CRC）在转移过程中通过谱系可塑性实现扩散的新机制。研究发现，播散性肿瘤细胞会暂时抑制肠道干细胞特性，转而诱导一种通常仅在表皮伤口愈合中活跃的遗传程序，并表达KRT17等特定角蛋白。这种状态受EZH2活性降低和YAP信号通路激活的共同驱动，使癌细胞获得类似基底细胞的迁移能力。通过类器官模型和临床样本验证，研究证实这种转化是可逆且可干预的，肿瘤细胞在成功定植远端器官后会重新获得原始特征。该发现为针对处于扩散阶段的隐匿癌细胞开发新型治疗策略提供了重要线索。References:Sakahara M, Okamoto T, Kumegawa K, et al. Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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1590-结直肠癌细胞转移中的伤口修复程序重塑
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