1592-颅骨骨髓转位蛋白与慢性疼痛的神经免疫关联

这项研究揭示了颅骨骨髓（SBM）在人类慢性疼痛机制中扮演着此前被忽视的关键角色。通过先进的PET/MRI影像技术，研究人员发现慢性背痛和膝关节炎患者颅骨中的18 kDa易位蛋白（TSPO）水平显著升高，这表明该部位存在活跃的免疫细胞聚集。这种免疫反应的强弱与患者感知的疼痛强度、心理焦虑及睡眠障碍等症状密切相关，且在空间分布上呈现出特定模式。初步的人体组织病理学分析进一步证实，疼痛患者的颅骨骨髓具有更高的细胞密度和免疫活性。这一发现挑战了大脑免疫系统处于隔离状态的传统观点，证明了颅骨与大脑之间存在紧密的神经免疫通讯。该成果不仅为理解慢性疼痛提供了全新的解剖学视角，也为开发针对骨髓免疫调节的创新疗法奠定了基础。References:Mohammadian M, Efthimiou N, Gabriel K, et al. Elevated translocator protein in skull bone marrow is linked to human chronic pain[J]. Science Translational Medicine, 2026, 18(865): eaed8729.前往小宇宙评论区与主播互动

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1592-颅骨骨髓转位蛋白与慢性疼痛的神经免疫关联

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