EPISODE · Sep 22, 2026 · 19 MIN
1599-高内皮静脉通过ALOX12驱动淋巴结肿瘤免疫逃逸
from 聊聊Sci
这项研究揭示了肿瘤细胞如何利用淋巴结中的高内皮静脉（HEV）实现免疫逃逸并向全身扩散。研究发现，肿瘤细胞通过分泌SEMA3C蛋白诱导HEV表达ALOX12酶，进而产生代谢物12-HETE。这种代谢分子能够促使肿瘤细胞内的ADAR1 p150蛋白与双链RNA发生液-液相分离，通过增强A-to-I RNA编辑来掩盖免疫信号，从而抑制干扰素反应。最终，从这些特殊血管进入循环的癌细胞具备了更强的抗免疫识别能力，显著增加了远端转移的风险。临床数据证实，HEV受累是乳腺癌患者预后不良的独立预测指标，为癌症治疗提供了潜在的新靶点。References:Xia Q, Pan J, Weng X, et al. Tumour-associated high endothelial venules drive portal-specific immune evasion in lymph nodes via ALOX12[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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1599-高内皮静脉通过ALOX12驱动淋巴结肿瘤免疫逃逸
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