16 - Instant insights: Lipoprotein fractionation for personalized risk assessment (8 min)

In this special episode of Healthier World designed to give you Instant Insights, we dive into advanced lipid testing—going beyond a standard lipid panel. Today, we will explore two powerful tools used to look at lipoprotein fractionation: ion mobility and nuclear magnetic resonance (NMR). We will look at how these tests work and how they can uncover hidden risk for cardiovascular disease. This episode will Expand on the importance of lipoprotein fractionation by ion mobility and nuclear magnetic resonance (NMR) (1:15) Interpret key lipid analytes provided using two methodologies, NMR and ion mobility, as they relate to cardiovascular disease risk (LDL: 3:00, HDL: 4:40, VLDL: 5:30, LDL pattern and LDL peak size: 6:00) Evaluate report analytes and risk cut points between methods (6:45) The content was current as of the time of recording. To learn more, please review the additional resources below for information on our cardiovascular, metabolic, endocrine, and wellness offerings as well as educational resources and insights from our team of experts. At Quest Diagnostics, we are committed to providing you with results and insights to support your clinical decisions. Date: 6/2025 Speaker(s):  Maeson Latsko, PhD Contributor(s):  Maeson Latsko, PhD; Trisha Winchester, PhD; Millicent Kee, MSN, FNP-BC; Abhi Patel   Additional Resources Ordering information: Quest Diagnostics Clinical Education Center [Link]   Fractionation, Ion Mobility Fractionation, NMR   References:           Cromwell WC, Otvos JD, Keyes MJ, et al. LDL Particle Number and Risk of Future Cardiovascular Disease in the Framingham Offspring Study - Implications for LDL Management. J Clin Lipidol. 2007;1(6):583-592. doi:10.1016/j.jacl.2007.10.001   German CA, Shapiro MD. Assessing Atherosclerotic Cardiovascular Disease Risk with Advanced Lipid Testing: State of the Science. Eur Cardiol. 2020;15:e56.  doi:10.15420/ecr.2019.18   Quesada JA, Bertomeu-González V, Orozco-Beltrán D, et al. The benefits of measuring the size and number of lipoprotein particles for cardiovascular risk prediction: A systematic review and meta-analysis. Clin Investig Arterioscler. 2023;35(4):165-177. doi:10.1016/j.arteri.2022.11.001