EPISODE · Sep 23, 2026 · 25 MIN
1601-纳米酶靶向RIG-I诱导细胞广谱凋亡增强癌症免疫治疗
from 聊聊Sci
这项研究开发了一种名为 Hemin-His-Mn 的新型肿瘤靶向纳米酶，旨在通过诱导PANoptosis（一种结合了凋亡、焦亡与坏死的混合细胞死亡模式）来增强癌症免疫治疗。该纳米酶具有双重功能：它既能作为激动剂解除 RIG-I 蛋白的自身抑制，触发 PANoptosome 复合物的组装，又能利用其类过氧化物酶活性产生大量活性氧以加速细胞死亡。这种机制能显著释放损伤相关分子模式（DAMPs），将“冷”肿瘤转变为“热”肿瘤，从而激活T细胞介导的抗肿瘤免疫反应。实验证明，该疗法能有效重塑肿瘤免疫微环境，并与免疫检查点阻断协同作用，为克服临床免疫耐药提供了极具潜力的临床转化方案。References:Dong S, Yuan Y, Cao H, et al. A RIG-I targeting nanozyme induces PANoptosis for cancer immunotherapy[J]. Nature Communications, 2026, 17: 6311.前往小宇宙评论区与主播互动
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1601-纳米酶靶向RIG-I诱导细胞广谱凋亡增强癌症免疫治疗
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