EPISODE · Sep 23, 2026 · 24 MIN
1602-供体微生物整合与黑色素瘤免疫治疗反应的关系
from 聊聊Sci
这项研究通过对三项临床试验的元基因组分析，探讨了粪便微生物移植（FMT）如何增强黑色素瘤患者对抗PD-1免疫疗法的反应。研究发现，治疗成功与否并不取决于微生物多样性的增加或特定菌种的植入，而在于供体菌株的成功整合以及肠道菌群的生态稳定性。疗效显著者表现出与供体更高的微生物相似性，并维持了稳定的菌群结构和功能；相比之下，无反应者则经历了剧烈的微生物载量波动和病原相关功能的增强。此外，肠道菌群的积极重塑与肿瘤微环境中免疫细胞的活化密切相关，这为克服免疫治疗耐药性提供了新的生态学视角。References:Fessler J L, Olm M R, Engleman E G, et al. Integration of donor microbiota following FMT correlates with anti-PD-1 response in melanoma[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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1602-供体微生物整合与黑色素瘤免疫治疗反应的关系
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