EPISODE · Sep 23, 2026 · 20 MIN
1604-纳米药物原位重编程肺泡巨噬细胞治疗肺癌
from 聊聊Sci
这篇论文介绍了一种利用纳米医学对肺部巨噬细胞进行原位重编程的创新型癌症免疫疗法。研究人员开发了一种精密设计的脂质体纳米颗粒（pCAR-P3/LNP），通过肺部雾化吸入精准识别并改造肺泡巨噬细胞，使其转化为具备识别肿瘤能力的CAR-AMs。这种改造后的细胞能通过增强吞噬作用、提升抗原递呈及诱导促炎性极化等多重机制，直接攻击肺癌细胞。实验证明，该策略不仅能显著抑制原发性肺肿瘤，还能有效激活免疫记忆并协同免疫检查点阻断疗法，从而抑制肿瘤的转移与复发。这种原位基因编辑技术规避了体外细胞操作的复杂性，为治疗包括肺癌在内的实体瘤提供了全新的临床思路。References:Li H, Lyu C, Cai X, et al. In situ reprogramming of CAR-alveolar macrophages via liposomal nanomedicine for lung cancer immunotherapy[J]. Nature Communications, 2026, 17(1): 7495.前往小宇宙评论区与主播互动
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1604-纳米药物原位重编程肺泡巨噬细胞治疗肺癌
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