EPISODE · Sep 23, 2026 · 15 MIN
1605-BRCA1缺失型乳腺癌微量残留病灶的时空演变与演化
from 聊聊Sci
这项研究通过整合单细胞测序、空间转录组学和成像质谱流式技术，深入探讨了乳腺癌微小残留病（MRD）的演变机制。研究人员利用BRCA1缺失型小鼠模型和人类临床样本，识别出一种对化疗具有高度耐受性的上皮-间质转化（EMT）肿瘤细胞群。这些细胞隐藏在特定的解剖空间龛位中，在治疗压力下保持稳定，并与患者的不良预后和高复发率显著相关。通过对比原发、残留及复发肿瘤的分子特征，研究揭示了MRD的动态可逆性，并发现针对EMT相关通路的药物干预能产生化疗协同增效作用。该成果为攻克三阴性乳腺癌的耐药性与复发难题提供了关键的空间生物学视角和潜在治疗靶点。References:Túrós D, Decollogny M, Moyseos A, et al. Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer[J]. Nature Communications, 2026.前往小宇宙评论区与主播互动
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1605-BRCA1缺失型乳腺癌微量残留病灶的时空演变与演化
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