EPISODE · Sep 24, 2026 · 21 MIN
1608-卵巢透明细胞癌空间转录组学异质性研究
from 聊聊Sci
这篇研究通过空间转录组学（ST）技术，深入探讨了卵巢透明细胞癌（OCCC）的内部异质性。研究团队利用多个队列的样本，揭示了肿瘤细胞在氧化磷酸化（OXPHOS）与上皮-间质转化（EMT）梯度上的分子演变规律。研究发现，具有LCN2高表达和低EMT特征的亚群通常与更好的临床预后相关，而SOX9基因在维持细胞上皮特性中起到关键作用。通过对主要病灶及转移部位的精准比对，科学家们解析了癌细胞与其微环境之间的动态交互机制。这些发现不仅提升了对OCCC复杂分子分型的认识，还为这种极具耐药性的癌症提供了潜在的治疗靶点和预后标志物。References:Le T T, Yi-Te Wang D, Yan S R G, et al. Spatial transcriptomic profiling of ovarian clear cell carcinoma reveals heterogeneity in OXPHOS and EMT gradients[J]. Nature Communications, 2026, 17: 8508.前往小宇宙评论区与主播互动
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1608-卵巢透明细胞癌空间转录组学异质性研究
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